When a culture of fear is in place, the desire to never make a mistake is so strong it can halt all progress. If failure is the ultimate enemy, we will do everything in our power to test, research, and plan for a failure-less scenario.
The problem: failure is inevitable.
But experimentation and creativity means there will also be failure, and that's not a bad thing. Failure means you know what not to do. Failure means you tried something new and different; it means your team is alive enough to take risks.
Fear of failure will lock the gears of an organization and guarantee stagnation. Be decisive, be confident in your decisions, and when you find you're headed the wrong direction, change quickly. A nimble, fast moving organization will see more success and creativity than one still at the starting line contemplating every possible outcome.